Project status: Terminated
Coordinator: IRCCS ICS Maugeri, Pavia (IT)
Start date: 01 January 2011
The CARDIO-i2b2 project aims to customize the i2b2 bioinformatics platform to integrate clinical and research data in order to support translational research in cardiology at FSM (Fondazione Salvatore Maugeri). CARDIO-i2b2 collects data from the Molecular Cardiology Laboratory databases and combines them with clinical data from the TRIAD system, an information system to collect data related to arrhythmogenic diseases. Genetic information related to affected patients is also collected.
The data contained in the TRIAD relational database were exported to the i2b2 data warehouse. A dedicated extension of i2b2 was developed to include static R software within the architecture and exploit the statistical capabilities of R via the i2b2 web interface. A dedicated plugin was developed to allow researchers to dynamically perform Kaplan-Meier survival analysis on selected patients.
Segagni D, Tibollo V, Dagliati A, Napolitano C, G Priori S, Bellazzi R. (2012) CARDIO-i2b2: integrating arrhythmogenic disease data in i2b2. Stud Health Technol Inform.180:1126-8. (link, pdf)
Segagni D, Tibollo V, Dagliati A, Malovini A, Zambelli A, Napolitano C, Priori SG, Bellazzi R. Clinical and research data integration: the i2b2-FSM experience. AMIA Jt Summits Transl Sci Proc. 2013 Mar 18;2013:239-40. eCollection 2013. (link)