The CARDIO-i2b2 project is an initiative to customize the i2b2 bioinformatics tool with the aim to integrate clinical and research data in order to support translational research in cardiology at FSM (Fondazione Salvatore Maugeri). CARDIO-i2b2 gathers data from the Molecular Cardiology Labs (MCL) databases and merges them with the clinical information from the TRIAD system, an electronic medical record (EMR) created to collect data related to specific arrhythmogenic diseases. Genetics information related to affected patients are also collected. Data contained into the TRIAD relational database was exported in the i2b2 data warehouse. A dedicated i2b2-cell was developed in order to include the R statistical software inside the IT architecture and exploit R statistical capabilities within the i2b2 web interface. To allow researchers to dynamically perform Kaplan-Meier survival analysis on selected patient and export values of interest into an Excel file, a web-client plugin and a data export plugin were developed and integrated into the i2b2 Plugins section (Figure 1).
Figure 1: The Kaplan-Meier survival analysis plugin
Segagni D, Tibollo V, Dagliati A, Napolitano C, G Priori S, Bellazzi R. (2012) CARDIO-i2b2: integrating arrhythmogenic disease data in i2b2. Stud Health Technol Inform.180:1126-8. (link, pdf)
Segagni D, Tibollo V, Dagliati A, Malovini A, Zambelli A, Napolitano C, Priori SG, Bellazzi R. Clinical and research data integration: the i2b2-FSM experience. AMIA Jt Summits Transl Sci Proc. 2013 Mar 18;2013:239-40. eCollection 2013. (pdf)